Publications

Xue, Christine, Lee, Yoon K, Tran, Joyce, Chang, Dennis, and Guo, Zhefeng. A mix-and-click method to measure amyloid-β concentration with sub-micromolar sensitivity. R. Soc. Open Sci., 4:170325. doi:10.1098/rsos.170325. (2017)

Xue, Christine, Lin, Tiffany Y, Chang, Dennis, and Guo, Zhefeng. Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation. R. Soc. Open Sci., 4: 160696. doi:10.1098/rsos.160696. PubMed PMID:28280572 PubMed Central PMC5319338 (2017)

Tran, Joyce, Chang, Dennis, Hsu, Frederick, Wang, Hongsu, and Guo, Zhefeng. Cross-seeding between Aβ40 and Aβ42 in Alzheimer’s disease. FEBS Lett., doi:10.1002/1873-3468.12526. Pubmed PMID:27981583 PubMed Central PMC5235972 (2016)

Gu, Lei, Tran, Joyce, Jiang, Lin, and Guo, Zhefeng. A new structural model of Alzheimer’s Aβ42 fibrils based on electron paramagnetic resonance data and rosetta modeling. J. Struct. Biol., 194:61-7. doi:10.1016/j.jsb.2016.01.013. PubMed PMID:26827680 PubMed Central PMC4764428 (2016).

Gu, Lei, Liu, Cong, Stroud, James C, Ngo, Sam, Jiang, Lin, Guo, Zhefeng. Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers. J. Biol. Chem. 289.:27300-13. doi: 10.1074/jbc.M114.569004. PubMed PMID:25118290 PubMed Central PMC4175361 (2014).

Gu, Lei, Liu, Cong, Guo, Zhefeng. Structural insights into Aβ42 oligomers using site-directed spin labeling. J. Biol. Chem. 288.:18673-83. doi: 10.1074/jbc.M113.457739. PubMed PMID:23687299 PubMed Central PMC3696641 (2013).

Gu, Lei, Guo, Zhefeng. Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils. J. Neurochem. 126.:305-11. doi: 10.1111/jnc.12202. PubMed PMID:23406382 PubMed Central PMC3716832 (2013).

Ngo, Sam, Chiang, Vicky, Ho, Elaine, Le, Linh, Guo, Zhefeng. Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. PLoS ONE. 7.:e47248. doi: 10.1371/journal.pone.0047248. PubMed PMID:23077577 PubMed Central PMC3473064 (2012).

Ngo, Sam, Chiang, Vicky, Guo, Zhefeng. Quantitative analysis of spin exchange interactions to identify β strand and turn regions in Ure2 prion domain fibrils with site-directed spin labeling. J. Struct. Biol. 180.:374-81. doi: 10.1016/j.jsb.2012.08.008. PubMed PMID:22967940 (2012).

Agopian, Agopian, Guo, Zhefeng. Structural origin of polymorphism of Alzheimer's amyloid β-fibrils. Biochem. J. 447.:43-50. doi: 10.1042/BJ20120034. PubMed PMID:22823461 (2012).

Gu, Lei, Ngo, Sam, Guo, Zhefeng. Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments. J. Biol. Chem. 287.:9081-9. doi: 10.1074/jbc.M111.292086. PubMed PMID:22277652 PubMed Central PMC3308762 (2012).

Ngo, Sam, Guo, Zhefeng. Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease. Biochem. Biophys. Res. Commun. 414.:512-6. doi: 10.1016/j.bbrc.2011.09.097. PubMed PMID:21986527 (2011).

Ngo, Sam, Gu, Lei, Guo, Zhefeng. Hierarchical organization in the amyloid core of yeast prion protein Ure2. J. Biol. Chem. 286.:29691-9. doi: 10.1074/jbc.M111.269092. PubMed PMID:21730048 PubMed Central PMC3191010 (2011).

López, Carlos J, Fleissner, Mark R, Guo, Zhefeng, Kusnetzow, Ana K, Hubbell, Wayne L. Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins. Protein Sci. 18.:1637-52. doi: 10.1002/pro.180. PubMed PMID:19585559 PubMed Central PMC2776952 (2009).

Guo, Zhefeng, Eisenberg, David. The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 17.:1617-23. doi: 10.1110/ps.036368.108. PubMed PMID:18552127 PubMed Central PMC2525518 (2008).

Guo, Zhefeng, Cascio, Dulio, Hideg, Kálmán, Hubbell, Wayne L. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci. 17.:228-39. doi: 10.1110/ps.073174008. PubMed PMID:18096642 PubMed Central PMC2222722 (2008).

Guo, Zhefeng, Cascio, Dulio, Hideg, Kálmán, Kálái, Támás, Hubbell, Wayne L. Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 16.:1069-86. doi: 10.1110/ps.062739107. PubMed PMID:17473014 PubMed Central PMC2206656 (2007).

Guo, Zhefeng, Eisenberg, David. The mechanism of the amyloidogenic conversion of T7 endonuclease I. J. Biol. Chem. 282.:14968-74. doi: 10.1074/jbc.M609514200. PubMed PMID:17360710 (2007).

Guo, Zhefeng, Eisenberg, David. Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc. Natl. Acad. Sci. U.S.A. 103.:8042-7. doi: 10.1073/pnas.0602607103. PubMed PMID:16698921 PubMed Central PMC1472426 (2006).

Li, Huiying, Guo, Zhefeng, Zhu, Yuxian. Molecular cloning and analysis of a pea cDNA that is expressed in darkness and very rapidly induced by gibberellic acid. Mol. Gen. Genet. 259:393-7. PubMed PMID:9790595 (1998).

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