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Gu, Lei; Guo, Zhefeng. Lipid membranes induce structural conversion from amyloid oligomers to fibrils. Biochem. Biophys. Res. Commun. 557:122-126. doi:10.1016/j.bbrc.2021.03.174. PubMed PMID:33862455. (2021). pdf
Liu, Emilie N; Park, Giovanna; Nohara, Junsuke; Guo, Zhefeng. Effect of spin labelling on the aggregation kinetics of yeast prion protein Ure2. R. Soc. Open Sci., 545:119-124. doi:10.1098/rsos.201747. PubMed PMID:33959337 PubMed Central PMC8074925. (2021). pdf
Yoon, Allison; Zhen, James; Guo, Zhefeng. Segmental structural dynamics in Aβ42 globulomers. Biochem. Biophys. Res. Commun. 545:119-124. doi:10.1016/j.bbrc.2021.01.081. PubMed PMID:33548624. (2021). pdf
Guo, Zhefeng. Amyloid hypothesis through the lens of Aβ supersaturation. Neural Regen. Res., 16:1562-1563. doi:10.4103/1673-5374.303021. PubMed PMID:33433483. (2021). pdf
Gu, Lei; Guo, Zhefeng. Alzheimer's Aβ42 and Aβ40 form mixed oligomers with direct molecular interactions. Biochem. Biophys. Res. Commun. 534:292-296. doi:10.1016/j.bbrc.2020.11.092. PubMed PMID:33272573. (2021). pdf
Park, Giovanna; Xue, Christine; Wang, Hongsu; Guo, Zhefeng. Distinguishing the effect on the rate and yield of Aβ42 aggregation by green tea polyphenol EGCG. ACS Omega, 5:21497-21505. doi:10.1021/acsomega.0c02063. PubMed PMID:32905372 PubMed Central PMC7469419. (2020). pdf
Wang, Jingzhou; Park, Giovanna; Lee, Yoon Kyung; Nguyen, Matthew; Fung, Tiffany San; Lin, Tiffany Yuwen; Hsu, Frederick; Guo, Zhefeng. Spin label scanning reveals likely locations of β-strands in the amyloid fibrils of the Ure2 prion domain. ACS Omega, 5:5984-5993. doi:10.1021/acsomega.9b04358. PubMed PMID:32226879. PubMed Central PMC7098000. (2020). pdf
Wang, Hongsu; Duo, Lan; Hsu, Frederick; Xue, Christine; Lee, Yoon Kyung; Guo, Zhefeng. Polymorphic Aβ42 fibrils adopt similar secondary structure but differ in cross-strand side chain stacking interactions within the same β-sheet. Sci. Rep., 10:5720. doi:10.1038/s41598-020-62181-x. PubMed PMID:32235842. PubMed Central PMC7109039. (2020) pdf
Xue, Christine; Tran, Joyce; Wang, Hongsu; Park, Giovanna; Hsu, Frederick; Guo, Zhefeng. Aβ42 fibril formation from predominantly oligomeric samples suggests a link between oligomer heterogeneity and fibril polymorphism. R. Soc. Open Sci., 6:190179. doi:10.1098/rsos.190179. PubMed PMID 31417723. PubMed Central PMC6689619. (2019). pdf
Wang, Hongsu; Lee, Yoon Kyung; Xue, Christine; Guo, Zhefeng. Site-specific structural order in Alzheimer’s Aβ42 fibrils. R. Soc. Open Sci., 5:180166. doi:10.1098/rsos.180166. PubMed PMID:30109072. PubMed Central PMC6083707. (2018) pdf
Hsu, Frederick; Park, Giovanna; Guo, Zhefeng. Key residues for the formation of Aβ42 amyloid fibrils. ACS Omega, 3:8401-9407. doi:10.1021/acsomega.8b00887. PubMed PMID:30087945. PubMed Central PMC6068601. (2018). pdf
Xue, Christine; Lee, Yoon K; Tran, Joyce; Chang, Dennis; Guo, Zhefeng. A mix-and-click method to measure amyloid-β concentration with sub-micromolar sensitivity. R. Soc. Open Sci., 4:170325. doi:10.1098/rsos.170325. PubMed PMID 28878984. PubMed Central PMC5579099. (2017). pdf
Xue, Christine; Lin, Tiffany Y; Chang, Dennis; Guo, Zhefeng. Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation. R. Soc. Open Sci., 4: 160696. doi:10.1098/rsos.160696. PubMed PMID:28280572. PubMed Central PMC5319338. (2017). pdf
Tran, Joyce; Chang, Dennis; Hsu, Frederick; Wang, Hongsu; Guo, Zhefeng. Cross-seeding between Aβ40 and Aβ42 in Alzheimer’s disease. FEBS Lett., doi:10.1002/1873-3468.12526. Pubmed PMID:27981583. PubMed Central PMC5235972. (2016). pdf
Gu, Lei; Tran, Joyce; Jiang, Lin; Guo, Zhefeng. A new structural model of Alzheimer’s Aβ42 fibrils based on electron paramagnetic resonance data and Rosetta modeling. J. Struct. Biol., 194:61-7. doi:10.1016/j.jsb.2016.01.013. PubMed PMID:26827680. PubMed Central PMC4764428. (2016). pdf
Gu, Lei; Liu, Cong; Stroud, James C; Ngo, Sam; Jiang, Lin; Guo, Zhefeng. Antiparallel triple-strand architecture for prefibrillar Aβ42 oligomers. J. Biol. Chem. 289.:27300-13. doi: 10.1074/jbc.M114.569004. PubMed PMID:25118290. PubMed Central PMC4175361. (2014).
Gu, Lei; Liu, Cong; Guo, Zhefeng. Structural insights into Aβ42 oligomers using site-directed spin labeling. J. Biol. Chem. 288.:18673-83. doi: 10.1074/jbc.M113.457739. PubMed PMID:23687299. PubMed Central PMC3696641. (2013).
Gu, Lei; Guo, Zhefeng. Alzheimer's Aβ42 and Aβ40 peptides form interlaced amyloid fibrils. J. Neurochem. 126.:305-11. doi: 10.1111/jnc.12202. PubMed PMID:23406382. PubMed Central PMC3716832. (2013). Cited by. pdf
Ngo, Sam; Chiang, Vicky; Ho, Elaine; Le, Linh; Guo, Zhefeng. Prion domain of yeast Ure2 protein adopts a completely disordered structure: a solid-support EPR study. PLoS ONE. 7.:e47248. doi: 10.1371/journal.pone.0047248. PubMed PMID:23077577. PubMed Central PMC3473064. (2012).
Ngo, Sam; Chiang, Vicky; Guo, Zhefeng. Quantitative analysis of spin exchange interactions to identify β strand and turn regions in Ure2 prion domain fibrils with site-directed spin labeling. J. Struct. Biol. 180.:374-81. doi: 10.1016/j.jsb.2012.08.008. PubMed PMID:22967940. (2012).
Agopian, Agopian; Guo, Zhefeng. Structural origin of polymorphism of Alzheimer's amyloid β-fibrils. Biochem. J. 447.:43-50. doi: 10.1042/BJ20120034. PubMed PMID:22823461. (2012).
Gu, Lei; Ngo, Sam; Guo, Zhefeng. Solid-support electron paramagnetic resonance (EPR) studies of Aβ40 monomers reveal a structured state with three ordered segments. J. Biol. Chem. 287.:9081-9. doi: 10.1074/jbc.M111.292086. PubMed PMID:22277652. PubMed Central PMC3308762. (2012).
Ngo, Sam; Guo, Zhefeng. Key residues for the oligomerization of Aβ42 protein in Alzheimer's disease. Biochem. Biophys. Res. Commun. 414.:512-6. doi: 10.1016/j.bbrc.2011.09.097. PubMed PMID:21986527. (2011).
Ngo, Sam; Gu, Lei; Guo, Zhefeng. Hierarchical organization in the amyloid core of yeast prion protein Ure2. J. Biol. Chem. 286.:29691-9. doi: 10.1074/jbc.M111.269092. PubMed PMID:21730048. PubMed Central PMC3191010. (2011).
López, Carlos J; Fleissner, Mark R; Guo, Zhefeng; Kusnetzow, Ana K; Hubbell, Wayne L. Osmolyte perturbation reveals conformational equilibria in spin-labeled proteins. Protein Sci. 18.:1637-52. doi: 10.1002/pro.180. PubMed PMID:19585559 PubMed Central PMC2776952 (2009).
Guo, Zhefeng; Eisenberg, David. The structure of a fibril-forming sequence, NNQQNY, in the context of a globular fold. Protein Sci. 17.:1617-23. doi: 10.1110/ps.036368.108. PubMed PMID:18552127 PubMed Central PMC2525518 (2008).
Guo, Zhefeng; Cascio, Dulio; Hideg, Kálmán; Hubbell, Wayne L. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Sci. 17.:228-39. doi: 10.1110/ps.073174008. PubMed PMID:18096642 PubMed Central PMC2222722 (2008).
Guo, Zhefeng; Cascio, Dulio; Hideg, Kálmán; Kálái, Támás; Hubbell, Wayne L. Structural determinants of nitroxide motion in spin-labeled proteins: tertiary contact and solvent-inaccessible sites in helix G of T4 lysozyme. Protein Sci. 16.:1069-86. doi: 10.1110/ps.062739107. PubMed PMID:17473014 PubMed Central PMC2206656 (2007).
Guo, Zhefeng; Eisenberg, David. The mechanism of the amyloidogenic conversion of T7 endonuclease I. J. Biol. Chem. 282.:14968-74. doi: 10.1074/jbc.M609514200. PubMed PMID:17360710 (2007).
Guo, Zhefeng; Eisenberg, David. Runaway domain swapping in amyloid-like fibrils of T7 endonuclease I. Proc. Natl. Acad. Sci. U.S.A. 103.:8042-7. doi: 10.1073/pnas.0602607103. PubMed PMID:16698921 PubMed Central PMC1472426 (2006).
Li, Huiying; Guo, Zhefeng; Zhu, Yuxian. Molecular cloning and analysis of a pea cDNA that is expressed in darkness and very rapidly induced by gibberellic acid. Mol. Gen. Genet. 259:393-7. PubMed PMID:9790595 (1998).